The chemical compound tert-Butyldi-methylsilyl chloride, also abbreviated as TBSCl, is an organosilicon compound with the formula Me2SiCl. Its main chemical properties are its silane, tert-Butyl group, and chloride. Read on for more information on TBSCl.
TBSCl is a common acronym for tert-Butyldi-methylsilyl chloride, which is an organosilicon compound. The formula is Me2SiCl, but is often abbreviated as TBSCl. This chloride is a silane that contains a reactive tert-Butyl group. It has been used as a chemical compound for more than 100 years.
Tert-Butyldi-Me2SiCl is an organosilicon compound with three methyl groups attached to its silicon atom. It is also an excellent derivatisation agent used in gas chromatography and mass spectrometry. However, despite its versatile uses, it is expensive. Nevertheless, if you’re looking for a reagent that won’t break the bank, you can make your own.
Historically, this compound (CAS:18162-48-6) has been used in organic synthesis as a silylating agent. However, its slow reaction rate led to unsatisfactory yields. Other silylation methods did not prove effective. However, the addition of dimethylformamide and imidazole, each with 1.2 eq. TBDMS-Cl, was successful in mild alcohol conversions. However, the onset of reactivity has caused further research to be done on its potential as a catalyzing agent.